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Biotechnology Progress

ISSN 1520-6033

2 papers in the library · 7 citations · publishing 2024

Papers

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Exploring the biocatalysis of psilocybin and other tryptamines: Enzymatic pathways, synthetic strategies, and industrial implications

Biotechnology Progress October 4, 2024 Lucas Henrique Junges, Marcelo Müller‐santos 5 citations

Abstract Tryptamines play diverse roles as neurotransmitters and psychoactive compounds found in various organisms. Psilocybin, a notable tryptamine, has garnered attention for its therapeutic potential in treating mental health disorders like depression and anxiety. Despite its promising applications, current extraction methods for psilocybin are labor‐intensive and economically limiting. We...

Evaluation of TrpM and PsiD substrate promiscuity reveals new biocatalytic capabilities

Biotechnology Progress June 18, 2024 Xin Wang, Fiona C. Kanis, Caroline N. Broude et al. 2 citations

Abstract N ‐methylated tryptamines, such as the hallucinogenic natural products, psilocybin and N,N ‐dimethyltryptamine (DMT), are gaining interest from the medical community due to their potential as next generation treatments for mental health disorders. The clinical relevance of these compounds has driven scientists to develop biosynthetic production routes to a number of tryptamine drug...