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Caroline N. Broude

2 papers in the library · 28 citations · publishing 2023-2024

Papers

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Evaluation of TrpM and PsiD substrate promiscuity reveals new biocatalytic capabilities

Biotechnology Progress June 18, 2024 Xin Wang, Fiona C. Kanis, Caroline N. Broude et al. 2 citations

Abstract N ‐methylated tryptamines, such as the hallucinogenic natural products, psilocybin and N,N ‐dimethyltryptamine (DMT), are gaining interest from the medical community due to their potential as next generation treatments for mental health disorders. The clinical relevance of these compounds has driven scientists to develop biosynthetic production routes to a number of tryptamine drug...

“Biosynthesis of psilocybin and its nonnatural derivatives by a promiscuous psilocybin synthesis pathway in Escherichia coli”

Biotechnology and Bioengineering June 20, 2023 Jessica E. Flower, William J Gibbons, Alexandra M. Adams et al. 26 citations

Abstract Traditional psychedelics are undergoing a transformation from recreational drugs, to promising pharmaceutical drug candidates with the potential to provide an alternative treatment option for individuals struggling with mental illness. Sustainable and economic production methods are thus needed to facilitate enhanced study of these drug candidates to support future clinical efforts....