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npj Aging

ISSN 2731-6068

2 papers in the library · 11 citations · publishing 2025-2026

Papers

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Psilocybin and human longevity

npj Aging April 3, 2026 Leonard Lerer

Psilocybin extends lifespan in aged mice, and this has prompted extensive media speculation about possible human longevity benefits. We examined mortality among prominent psychedelic personalities, researchers, and advocates who claimed psychedelic use (n = 11) and compared them with cancer (n = 12) and aging researchers (n = 5). All groups exceeded population life expectancy, reflecting the...

Psilocybin treatment extends cellular lifespan and improves survival of aged mice

npj Aging July 8, 2025 Kosuke Kato, Yoon-Joo Shin, Cristian Coarfa et al. 11 citations

Abstract Psilocybin, the naturally occurring psychedelic compound produced by hallucinogenic mushrooms, has received attention due to considerable clinical evidence for its therapeutic potential to treat various psychiatric and neurodegenerative indications. However, the underlying molecular mechanisms remain enigmatic, and few studies have explored its systemic impacts. We provide the first...