Research Square (Research Square)
February 23, 2024
Ari Brouwer, Joshua K. Brown, Earth Erowid et al.
5 citations
Abstract Psychedelic therapy has the potential to become a revolutionary and transdiagnostic mental health treatment, yielding enduring benefits that are often attributed to the experiences that coincide with peak psychedelic effects. However, there may be an underrecognized temporal structure to this process that helps explain why psychedelic and related altered states of consciousness can...
Research Square (Research Square)
January 4, 2024
Laetitia Vanderijst, Felix Hever, Anne Buot et al.
Abstract Background: A significant number of individuals with alcohol use disorder remain unresponsive to currently available treatments, which calls for the development of new alternatives. In parallel, psilocybin-assisted therapy for alcohol use disorder has recently yielded promising preliminary results. Building on extant findings, the proposed study is set to evaluate the feasibility and...
Research Square (Research Square)
November 14, 2023
Félix Schoeller, Abhinandan Jain, Vladimir Adrien et al.
2 citations
Abstract Background Depression is a major global health challenge, affecting over 300 million people worldwide. Current pharmacological and psychotherapeutic interventions have limited efficacy, underscoring the need for novel approaches. Emerging evidence suggests that peak emotional experiences characterized by awe, transcendence, and meaning hold promise for rapidly shifting maladaptive...
Research Square (Research Square)
August 23, 2023
Lucas Villar Magalhães da Cruz, Bheatrix Bienemann Favero, Fernanda Palhano-Fontes et al.
Abstract Ayahuasca is a brew with psychoactive properties that has been used as an entheogen for centuries, with more recent studies suggesting it is a promising treatment for some clinical disorders. Although there is an emerging scientific literature on its effects, to the best of our knowledge no study has explored the self-reported experiences of first-time ayahuasca users with quantitative...
Research Square (Research Square)
July 27, 2023
Claire Finkelstein, Olivia Soha, Alana Roy et al.
2 citations
Abstract Background: Body Image Disturbance (BID) is the distorted experience of one’s body. BID presents a risk for the onset, maintenance and relapse of body dysmorphic disorder and eating disorders, including anorexia nervosa (AN). Current treatments tend to focus on the cognitive and behavioural aspects while overlooking the perceptual symptoms and BID frequently persists beyond physical...
Research Square (Research Square)
July 18, 2023
Sanah Malomile Nkadimeng, L. Hay, Christiaan Ml Steinmann et al.
1 citation
Abstract Background Psilocybin-containing mushrooms induce antidepressant and momentary increase in blood pressure (BP) with potential risk to users with cardiovascular diseases. Irregularities in nitric oxide (NO) levels play a key role in endothelial dysfunctions leading to increases in BP. Mushrooms species show large variation in potency which may potentially induce different outcomes and...
Research Square (Research Square)
July 7, 2023
Rika Takaba, Daisuke Ibi, Keisuke Yoshida et al.
4 citations
Abstract Serotonergic psychedelics such as psilocybin, lysergic acid diethylamide, and DOI exert a hallucinatory effect through serotonin 5-HT 2A receptor (5-HT2A) activation. Recent studies have revealed that serotonergic psychedelics have therapeutic potential for neuropsychiatric disorders, including major depressive and anxiety-related disorders. However, the involvement of 5-HT2A in...
Research Square (Research Square)
May 12, 2023
Gabriel Thorens, Louise Penzenstadler, Leonice Furtado et al.
Abstract Case report of a patient with GAD and claustrophobia who underwent exposure therapy using psilocybin-assisted psychotherapy. The patient had failed to respond to conventional psychotherapeutic treatment. After three sessions of psilocybin-assisted psychotherapy, the patient experienced a reduction in anxiety and fear associated with closed spaces, elevators, and planes. The protocol...
Research Square (Research Square)
March 21, 2022
Maddie Palmer, Olivia Maynard
4 citations
Abstract Background. Alongside a recent revival in the use of psychedelics in clinical settings, there have been increases in the prevalence of recreational use, with many using psychedelics to deal with difficult emotions or to improve wellbeing. While clinical research is conducted in carefully controlled settings, this is not necessarily the case for recreational use. In this mixed-methods...
Research Square (Research Square)
March 8, 2022
Gabriella Smedfors, Elliot J. Glotfelty, Negar Kalani et al.
8 citations
Abstract Psilocybin is a psychedelic substance approaching clinical use. The drug has long-lasting effects after single or multiple administrations and enhances structural plasticity in the brain. Little is known if the plasticity inducing effects of psilocybin could be timed to other treatments and promote a larger effect. We investigated the effect of psilocybin on cultured mouse hippocampal...
Research Square (Research Square)
January 25, 2022
Joseph T. la Torre, Mehdi Mahammadli, Kyle T. Greenway et al.
18 citations
Abstract Background Currently, personal or familial histories of psychotic symptoms are exclusionary criteria for most psychedelic clinical trials, studies, and treatment programs. This study sought to determine why such an exclusion exists, what the implications of the exclusion criteria are, and if there was agreement in expert opinion. Methods In-depth interviews with 12 experts in the...
Research Square (Research Square)
November 30, 2020
Brandon Weiss, Joshua D. Miller, Nathan T. Carter et al.
7 citations
Abstract The present study examines the association between the ceremonial use of ayahuasca – a decoction combining the Banistereopsis caapi vine and N,N Dimethyltryptamine-containing plants – and changes in personality traits as conceived by the Five-Factor model (FFM); as well as the degree to which demographic characteristics, baseline personality, and acute post-ayahuasca experiences affect...
Research Square (Research Square)
Adam Włodarczyk, Wiesław Jerzy Cubała, Maria Węgielnik-gałuszko et al.
Abstract Background and objectives: There is evidence for ketamine use in treatment-resistant depression (TRD). Several safety and tolerability concerns arise regarding adverse drug reactions and specific subpopulations. The aim of this paper is to investigate the relationship between dissociative and psychometric measures in course of intravenous ketamine treatment in TRD inpatients with Major...