Aggression and violent behavior

Targeting Serotonin 5-HT2A Receptors in the Treatment of Aggression: from Antipsychotics to Psychedelics.

Aggression and violent behavior 2026 Simona Scheggi, Giulia Braccagni, Caterina Branca et al.

Aggression, anger, and irritability emerge from dysregulated interactions between prefrontal and limbic circuits, with serotonin (5-HT) exerting a central regulatory influence. Among serotonergic targets, the 5-HT2A receptor has emerged as a key modulator of aggressive behavior. Convergent neuroimaging, postmortem, and preclinical studies consistently implicate heightened prefrontal 5-HT2A...