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Canadian Journal of Addiction

ISSN 2368-4739

1 paper in the library · publishing 2026

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A Diagnostic Challenge in Polysubstance Use: Nitrous Oxide–induced Neurological Toxicity Masked by Alcohol Withdrawal—A Case Report

Canadian Journal of Addiction August 7, 2026 Lucy Doan, Leisha Hawker, Caroline Racz

ABSTRACT Background: Recreational nitrous oxide use is increasing, causing functional vitamin B 12 deficiency and neurological complications that may be overlooked in complex clinical presentations. Case presentation: A 26-year-old male with alcohol use disorder presented with progressive lower-extremity weakness, peripheral paresthesias, and nocturnal urinary incontinence during alcohol...