Long-term opioid use is associated with pharmacological tolerance, a risk of misuse and hyperalgesia in patients with chronic pain (CP). Tapering is challenging in this context, particularly with comorbid opioid-use disorder (OUD). The antihyperalgesic effect of ketamine, through N-methyl-D-aspartate (NMDA) antagonism, could be useful. We aimed to describe the changes in the dose of opioids...
The N-methyl-D-aspartate receptor (NMDAR) has been linked to the development of chronic postsurgical pain (CPSP), defined as pain after surgery that does not resolve by 3 months. Once the combination of a painful stimulus and glutamate binding activates the NMDAR, calcium influx triggers signaling cascades that lead to processes like central sensitization and CPSP. Three of the most widely...
Castellanos JP, Woolley C, Bruno KA, et al . Chronic pain and psychedelics: a review and proposed mechanism of action. Reg Anesth Pain Med 2020;45:486–94. doi:10.1136/rapm-2020–101273. This article has been corrected due to multiple referencing errors. Some references had become misordered
Dear Editor We read with great interest the article by Castellanos et al [1][1] in a recent issue of the journal. The authors performed a review on the use of psychedelics in pain medicine and concluded that there may be benefit in exploring psychadelics as a medicinal treatment modality for