Low-dose ketamine infusion to facilitate opioid tapering in chronic non-cancer pain with opioid-use disorder: a historical cohort study.
Regional Anesthesia & Pain Medicine May 6, 2025 Antoine Elyn, Anne Roussin, Cécile Lestrade et al. 8 citations
Long-term opioid use is associated with pharmacological tolerance, a risk of misuse and hyperalgesia in patients with chronic pain (CP). Tapering is challenging in this context, particularly with comorbid opioid-use disorder (OUD). The antihyperalgesic effect of ketamine, through N-methyl-D-aspartate (NMDA) antagonism, could be useful. We aimed to describe the changes in the dose of opioids...
DOI: 10.1136/rapm-2023-105035 (opens in new tab)
Full text (opens in new tab)
Analgesics, opioid
Opioid-related disorders
Ketamine therapy
Chronic pain management
+3