Eric S Schwenk

N-Methyl-D-aspartate receptor antagonists for the prevention of chronic postsurgical pain: a narrative review.

Regional Anesthesia & Pain Medicine February 5, 2025 Jeffrey Jon Mojica, Grace Eddy, Eric S Schwenk 5 citations

The N-methyl-D-aspartate receptor (NMDAR) has been linked to the development of chronic postsurgical pain (CPSP), defined as pain after surgery that does not resolve by 3 months. Once the combination of a painful stimulus and glutamate binding activates the NMDAR, calcium influx triggers signaling cascades that lead to processes like central sensitization and CPSP. Three of the most widely...