Antagonism of 5-methoxy-N,N-dimethyltryptamine-induced changes in postdecapitation convulsions in rats by repeated treatment with drugs enhancing 5-hydroxytryptamine neurotransmission.
The Journal of pharmacy and pharmacology September 1, 1985 T Archer, B Tandberg, L Rényi et al. 8 citations
Repeated administration of drugs that increase tryptaminergic neurotransmission blocked the effects of an acute injection of 5-MeODMT on postdecapitation convulsions in rats. Zimelidine, fluoxetine, amiflamine, and alpha-ethyltryptamine given orally over 10 days substantially blocked the increase in latency and duration of convulsions caused by 5-MeODMT, while alaproclate, clorgyline, and pargyline caused a lesser blockade. Repeated 5-MeODMT administration completely blocked the acute effects. These findings suggest down-regulation of serotonin receptors mediating the convulsion response and offer a simple model for studying receptor sensitivity changes at the spinal level.