Topics in current chemistry

Synthesis of neoclerodane diterpenes and their pharmacological effects.

Topics in current chemistry 2011 Kimberly M Lovell, Katherine M Prevatt-Smith, Anthony Lozama et al. 17 citations

Salvinorin A is a neoclerodane diterpene that has been shown to be an agonist at kappa opioid receptors. Its unique structure makes it an attractive target for synthetic organic chemists due to its seven chiral centers and diterpene scaffold. This molecule is also interesting to pharmacologists because it is a non-serotonergic hallucinogen, and the first opioid ligand discovered that lacks a...