The rapid antidepressant effect of ketamine is arguably one of the most significant advances in the mental health field in the last half century. However, its mechanism of action has remained elusive. Here, we describe our latest discovery on how ketamine blocks N-methyl-D-aspartate receptor (NMDAR)-dependent burst firing of an "antireward" center in the brain, the lateral habenula (LHb), to...
Koch 1990) that outlined a sketch of such a theory. Our aim was not to produce as complete a theory of con-sciousness as possible but to indicate promising lines of experimental work, mainly neurobiological, that might lead eventually toward a solution of the problem. We made the plausible assumption that all forms of con-sciousness (e.g., seeing, thinking, and pain) employ, at bottom, rather...