Biomedical chromatography : BMC
September 1, 2025
Jan Thomann, Selina Kraus, Livio Erne et al.
1 citation
Ketamine, a well-established dissociative anesthetic, has recently gained significant attention for its rapid-acting antidepressant effects, particularly in treatment-resistant depression. In this study, we developed and validated a state-of-the-art liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for the bioanalysis of ketamine and its metabolites, norketamine,...
Biomedical chromatography : BMC
December 1, 2013
Steven A. Barker, Jimo Borjigin, Izabela Lomnicka et al.
73 citations
We report a qualitative liquid chromatography-tandem mass spectrometry (LC/MS/MS) method for the simultaneous analysis of the three known N,N-dimethyltryptamine endogenous hallucinogens, their precursors and metabolites, as well as melatonin and its metabolic precursors. The method was characterized using artificial cerebrospinal fluid (aCSF) as the matrix and was subsequently applied to the...
Biomedical chromatography : BMC
March 1, 2012
Ethan H. Mcilhenny, Jordi Riba, Manel J. Barbanoj et al.
57 citations
There is an increasing interest in potential medical applications of ayahuasca, a South American psychotropic plant tea with a long cultural history of indigenous medical and religious use. Clinical research into ayahuasca will require specific, sensitive and comprehensive methods for the characterization and quantitation of these compounds and their metabolites in blood. A combination of two...
Biomedical chromatography : BMC
September 1, 2011
Ethan H. Mcilhenny, Jordi Riba, Manel J. Barbanoj et al.
51 citations
Ayahuasca, also known as caapi or yage among various South American groups, holds a highly esteemed and millennia-old position in these cultures' medical and religious pharmacopeia. There is now an increasing interest in the potential for modern medical applications of ayahuasca, as well as concerns regarding its increasing potential for abuse. Toxicological and clinical research to address...