BACKGROUND: Salvinorin-A is a terpene found in the leaves of the plant Salvia divinorum. When administered to humans, salvinorin-A induces an intense but short-lasting modified state of awareness, sharing features with those induced by the classical serotonin-2A receptor agonist psychedelics. However, unlike substances such as psilocybin or mescaline, salvinorin-A shows agonist activity at the...
FigshareDecember 3, 2015Ekman Schenberg Eduardo, Felipe Morel Alexandre João, Renato Filev et al.
<p>Concentration (mg/ml) of 13 compounds screened in the <i>Hoasca</i> tea, estimated ingested dose (mg/kg) and total amount ingested of each compound (mg).</p><p>Concentration of chemical compounds in Ayahuasca.</p>
Ritual use of ayahuasca, an amazonian Amerindian medicine turned sacrament in syncretic religions in Brazil, is rapidly growing around the world. Because of this internationalization, a comprehensive understanding of the pharmacological mechanisms of action of the brew and the neural correlates of the modified states of consciousness it induces is important. Employing a combination of...