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PLoS Computational Biology

ISSN 1553-7358

28 papers in the library · 1,843 citations · publishing 2007-2026

Papers

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Noise during rest enables the exploration of the brain's dynamic repertoire.

PLoS Computational Biology October 1, 2008 Anandamohan Ghosh, Y Rho, A R McIntosh et al.

Traditionally brain function is studied through measuring physiological responses in controlled sensory, motor, and cognitive paradigms. However, even at rest, in the absence of overt goal-directed behavior, collections of cortical regions consistently show temporally coherent activity. In humans, these resting state networks have been shown to greatly overlap with functional architectures...

Integrated Information in Discrete Dynamical Systems: Motivation and Theoretical Framework

PLoS Computational Biology June 12, 2008 David Balduzzi, Giulio Tononi 433 citations

This paper introduces a time- and state-dependent measure of integrated information, phi, which captures the repertoire of causal states available to a system as a whole. Specifically, phi quantifies how much information is generated (uncertainty is reduced) when a system enters a particular state through causal interactions among its elements, above and beyond the information generated...

DOI: 10.1371/journal.pcbi.1000091 (opens in new tab) Function biology Modular design Repertoire State computer science +7

A Dynamical Systems Hypothesis of Schizophrenia

PLoS Computational Biology November 7, 2007 Marco Loh, Edmund T Rolls, Gustavo Deco 172 citations

We propose a top-down approach to the symptoms of schizophrenia based on a statistical dynamical framework. We show that a reduced depth in the basins of attraction of cortical attractor states destabilizes the activity at the network level due to the constant statistical fluctuations caused by the stochastic spiking of neurons. In integrate-and-fire network simulations, a decrease in the NMDA...

DOI: 10.1371/journal.pcbi.0030228 (opens in new tab) Attractor Schizophrenia object-oriented programming Prefrontal cortex Instability +12