Pain is a common symptom of cancer and its treatment, yet it is often undertreated due to complex biology and reduced opioid prescribing. Cancer diagnosis and pain can trigger high levels of psychological distress, including anxiety, depression, and fear of death or recurrence. Psychedelics such as LSD, psilocybin, mescaline, and DMT are being investigated as new strategies to manage both cancer pain and associated distress. Although published studies are limited, regulatory hurdles have decreased, and many clinical trials are underway. Early results are promising, but further research is needed to understand efficacy and tolerability in broader cancer populations.
Testicular cancer survivors often face diminished health-related quality of life due to identity disruptions, fear of recurrence, and sexual dysfunction, yet few interventions address these multidimensional stressors. This narrative review examines existing literature and evaluates mindfulness-based interventions as a potential therapeutic strategy. Evidence from broader cancer populations shows that mindfulness practices can reduce psychological distress and improve emotional regulation. The authors note that no fully developed mindfulness trials have been designed specifically for testicular cancer survivors, and they call for implementing such strategies to enhance post-treatment outcomes and reduce disparities in male mental health care.