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Proc Natl Acad Sci U S A

ISSN 0027-8424; 1091-6490;

15 papers in the library · 1,389 citations · publishing 1958-2025

Papers

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If psychedelics heal, how do they do it?

Proc Natl Acad Sci U S A January 3, 2024 Carolyn Beans

Understanding the biological basis of social anxiety disorder (SAD), one of the most disabling of the anxiety disorders, will allow for novel treatment strategies to be developed. Here, we show that gut microbiota may be such a target. Mice ...Social anxiety disorder (SAD) is a crippling psychiatric disorder characterized by intense fear or anxiety in social situations and their avoidance....

Consciousness is supported by near-critical slow cortical electrodynamics.

Proc Natl Acad Sci U S A February 1, 2022 Daniel Toker, Ioannis Pappas, Janna D. Lendner et al. 148 citations

Mounting evidence suggests that during conscious states, the electrodynamics of the cortex are poised near a critical point or phase transition and that this near-critical behavior supports the vast flow of information through cortical networks during conscious states. Here, we empirically identify a mathematically specific critical point near which waking cortical oscillatory dynamics operate,...

Effective connectivity changes in LSD-induced altered states of consciousness in humans.

Proc Natl Acad Sci U S A January 28, 2019 Katrin H. Preller, Adeel Razi, Peter Zeidman et al. 303 citations

Psychedelics exert unique effects on human consciousness. The thalamic filter model suggests that core effects of psychedelics may result from gating deficits, based on a disintegration of information processing within cortico-striato-thalamo-cortical (CSTC) feedback loops. To test this hypothesis, we characterized changes in directed (effective) connectivity between selected CTSC regions after...

Neural correlates of the LSD experience revealed by multimodal neuroimaging.

Proc Natl Acad Sci U S A April 11, 2016 Robin Carhart-Harris, Suresh Muthukumaraswamy, Leor Roseman et al. 887 citations

Lysergic acid diethylamide (LSD) is the prototypical psychedelic drug, but its effects on the human brain have never been studied before with modern neuroimaging. Here, three complementary neuroimaging techniques: arterial spin labeling (ASL), blood oxygen level-dependent (BOLD) measures, and magnetoencephalography (MEG), implemented during resting state conditions, revealed marked changes in...