NMDA Antagonist Neurotoxicity: Mechanism and Prevention
Science December 6, 1991 J. W. Olney, J. Labruyere, G. Wang et al. 850 citations
Antagonists of the N-methyl-D-aspartate (NMDA) subtype of glutamate receptor, including phencyclidine (PCP) and ketamine, protect against brain damage in neurological disorders such as stroke. However, these agents have psychotomimetic properties in humans and morphologically damage neurons in the cerebral cortex of rats. It is now shown that the morphological damage can be prevented by certain...