ED95 of esketamine for reducing preoperative anxiety in children of different ages
Research Square November 11, 2025 Xuming Zhu, Xiaoyong Wei, Qianyu Guo et al.
Abstract Background: The incidence of preoperative anxiety in children is significantly higher than in adults. Esketamine, the dextrorotatory enantiomer of ketamine, has been shown to alleviate preoperative anxiety in children effectively. Previous studies have established the effective dose (ED 50 ) of esketamine for reducing anxiety in pediatric patients. However, the 95% effective dose (ED...