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Jackson Raffety

2 papers in the library · publishing 2025-2026

Papers

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Cross-species mapping of acute psychedelic-responsive genes links HTR2A cortical expression, cell-type enrichment, and human cortical expression modules

Translational Psychiatry August 1, 2026 Patrick A. McConnell, Jackson Raffety, Andrew Li et al.

Abstract Psychedelic drugs exert rapid and profound effects on human consciousness [1–7] and are increasingly being investigated for their therapeutic potential [8–14]. Yet the transcriptional programs through which they may reshape brain function and structure remain incompletely understood, in part because the available evidence is heterogeneous and largely preclinical [15, 16]. In a...

Cross-species mapping of psychedelic gene expression reveals links to the 5HT2A receptor, cortical layers, and human accelerated regions

Research Square October 3, 2025 Patrick A. McConnell, Jackson Raffety, Andrew Li et al. preprint

Abstract Psychedelic drugs exert rapid and profound effects on human consciousness and are increasingly explored for their clinical potential. Yet, the genetic programs through which psychedelics reshape brain function and structure remain incompletely understood, in part because most studies have been conducted in preclinical models and cell cultures. We conducted a systematic literature...

DOI: 10.21203/rs.3.rs-7625999/v1 (opens in new tab) Psychedelics Compounds Psychedelic action Gene expression +10