Serotonergic psychedelics such as LSD, psilocybin, and DMT alter consciousness and may help treat depression and addiction, but their mechanisms remain unclear. A systematic review and meta-analysis across three levels—subjective experience, neuroimaging, and molecular pharmacology—reveals that medium and high doses of LSD produce stronger visionary restructuring than psilocybin. Neuroimaging shows psychedelics generally strengthen connectivity between brain networks while weakening connectivity within networks. Pharmacologically, LSD triggers more inositol phosphate formation at the 5-HT2A receptor than DMT or psilocin, but no significant differences exist in receptor selectivity among the drugs. The analysis finds high heterogeneity and risk of bias, calling for standardized methods and more research.
The Museum of Consciousness presents a collection of short audio samples designed by artists and consciousness explorers to cultivate expansive states of consciousness. The samples include mindfulness meditations, placebo highs, sound journeys, and novel introspection methods. Visitors rate each sample using Raph Milliere's 6D model of self-consciousness, which was inspired by psychedelics and meditation, and play a game guessing the curators' pre-assigned ratings. Feedback from visitors is incorporated into a regenerative system that shapes future exhibits.
This correction notice addresses errors in a previously published article that presented three systematic reviews and meta-analyses examining the pharmacology, neuroimaging, and phenomenology of psychedelics. The correction does not provide new findings or data but serves to amend the original publication.