REBUS and the Anarchic Brain: Toward a Unified Model of the Brain Action of Psychedelics
Pharmacological Reviews June 20, 2019 R.L. Carhart-Harris, K.J. Friston 1,163 citations
This paper formulates the action of psychedelics by integrating the free-energy principle and entropic brain hypothesis. We call this formulation relaxed beliefs under psychedelics (REBUS) and the anarchic brain, founded on the principle that-via their entropic effect on spontaneous cortical activity-psychedelics work to relax the precision of high-level priors or beliefs, thereby liberating...