Bioproduction of 3,4-methylenedioxymethamphetamine and derivatives.
Biodesign research June 1, 2025 Natali Ozber, Jing Li, Peter J. Facchini 2 citations
3,4-Methylenedioxymethamphetamine (MDMA, Ecstasy) is a recreational drug under clinical investigation for the treatment of central nervous system disorders, including post-traumatic stress disorder. Chemical synthesis of MDMA mainly relies on the use of safrole and piperonal as starting materials. We report a novel strategy integrating bioconversion and biocatalysis in the bioproduction of MDMA...