David R Maguire

2 papers in the library · 2 citations · publishing 2024-2025

Papers

Evaluation of potential punishing effects of 2,5-dimethoxy-4-methylamphetamine (DOM) in rhesus monkeys responding under a choice procedure.

Behavioural Pharmacology October 1, 2024 David R Maguire 2 citations

A 5-HT2A receptor agonist called DOM, tested in four rhesus monkeys using a choice procedure, showed neither rewarding nor punishing effects. When monkeys chose between a sucrose pellet alone or a pellet plus an intravenous infusion, fentanyl increased choice for the infusion (rewarding), while histamine decreased it (punishing). DOM, tested across doses of 3.2 to 100 µg/kg/infusion, did not systematically alter choice, whether given before or after histamine. This suggests DOM lacks both positive reinforcing and aversive properties under conditions sensitive to these effects.

DOI: 10.1097/fbp.0000000000000787 Full text

Interactions between fentanyl and 2,5-dimethoxy-4-methylamphetamine: Ventilatory effects in nonhuman primates.

The Journal of pharmacology and experimental therapeutics October 1, 2025 David R Maguire

In rhesus monkeys, the psychedelic DOM exacerbated fentanyl-induced breathing depression, increasing overdose risk. Fentanyl alone dose-dependently reduced tidal volume, while DOM alone had no effect. However, combining DOM with fentanyl decreased ventilation more than fentanyl alone in most monkeys. These findings suggest that serotonergic hallucinogens like DOM may worsen opioid-induced ventilatory depression, though it remains unclear whether this extends to other opioids or similar drugs.

DOI: 10.1016/j.jpet.2025.103691 Full text Dom Fentanyl Minute volume Nonhuman primates +1