Adenosine signalling drives antidepressant actions of ketamine and ECT
Nature November 5, 2025 Chenyu Yue, Nan Wang, Haojiang Zhai et al. 22 citations
Ketamine and electroconvulsive therapy (ECT) achieve rapid remission in treatment-resistant depression. However, their mechanisms of action—the understanding of which is essential for refining therapeutic precision—remain unclear1, 2–3. Here, using mouse models, we identify adenosine signalling as a central pathway that underlies the antidepressant effects of these interventions. Results from...