A. Nierenberg

2 papers in the library · 139 citations · publishing 2021-2022

Papers

Efficacy and Safety of Ketamine vs Electroconvulsive Therapy Among Patients With Major Depressive Episode: A Systematic Review and Meta-analysis.

JAMA Psychiatry October 19, 2022 T. Rhee, S. Shim, B. Forester et al. 139 citations

A systematic review and meta-analysis of six clinical trials involving 340 patients with major depressive episodes found that electroconvulsive therapy (ECT) was more effective than ketamine for reducing depression severity in the acute phase, with a standardized mean difference of -0.69 favoring ECT. No significant differences were observed between the two treatments for cognition, memory, or serious adverse events. Ketamine carried lower risks of headache and muscle pain, while ECT carried lower risks of blurred vision, vertigo, diplopia, and dissociative symptoms. The findings suggest ECT may be superior, but treatment decisions should be individualized.

DOI: 10.1001/jamapsychiatry.2022.3352 Full text Medicine

Restoration of default mode network and task positive network anti-correlation associated with mindfulness-based cognitive therapy for bipolar disorder

Psychiatry research. Neuroimaging November 1, 2021 Tina Chou, Darin D. Dougherty, A. Nierenberg et al.

Individuals with bipolar disorder (BP) show abnormally positive coupling between the default mode network (DMN) and task positive network (TPN), two brain networks that are normally anti-correlated. After 12 weeks of mindfulness-based cognitive therapy (MBCT), BP participants exhibited restored negative coupling between these networks, similar to healthy controls. Supportive psychotherapy produced no significant change. The finding suggests MBCT can normalize DMN-TPN connectivity in BP.

DOI: 10.1016/j.pscychresns.2021.111419 Full text Medicine Psychology