Restoration of default mode network and task positive network anti-correlation associated with mindfulness-based cognitive therapy for bipolar disorder
Psychiatry research. Neuroimaging November 1, 2021 Tina Chou, Darin D. Dougherty, A. Nierenberg et al.
Individuals with bipolar disorder (BP) show abnormally positive coupling between the default mode network (DMN) and task positive network (TPN), two brain networks that are normally anti-correlated. After 12 weeks of mindfulness-based cognitive therapy (MBCT), BP participants exhibited restored negative coupling between these networks, similar to healthy controls. Supportive psychotherapy produced no significant change. The finding suggests MBCT can normalize DMN-TPN connectivity in BP.