SUMMARY The prototypical hallucinogen LSD acts via serotonin receptors, and here we describe the crystal structure of LSD in complex with the human serotonin receptor 5-HT2B. The complex reveals conformational rearrangements to accommodate LSD, providing a structural explanation for the conformational selectivity of LSD’s key diethylamide moiety. LSD dissociates exceptionally slowly from both...
It is 10:00 Friday morning at the Yale School of Nursing in New Haven, Connecticut. I greet students as they arrive for the fifth session of an elective course entitled "The Stress Reduction and Relaxation Program." This eight week program provides intensive training in mindfulness meditation, and introduces meditation as a therapeutic intervention in the health care system. There are 20...