Nature
September 28, 2022
Anat Levit Kaplan, Danielle N. Confair, Kuglae Kim et al.
There is considerable interest in screening ultralarge chemical libraries for ligand discovery, both empirically and computationally 1 – 4 . Efforts have focused on readily synthesizable molecules, inevitably leaving many chemotypes unexplored. Here we investigate structure-based docking of a bespoke virtual library of tetrahydropyridines—a scaffold that is poorly sampled by a general...
PLoS One
March 22, 2018
B. Roth, Simon Gibbons, Warunya Arunotayanun et al.
correction
[This corrects the article DOI: 10.1371/journal.pone.0059334.].
Cell
January 26, 2017
Daniel Wacker, Sheng Wang, John D. Mccorvy et al.
466 citations
SUMMARY The prototypical hallucinogen LSD acts via serotonin receptors, and here we describe the crystal structure of LSD in complex with the human serotonin receptor 5-HT2B. The complex reveals conformational rearrangements to accommodate LSD, providing a structural explanation for the conformational selectivity of LSD’s key diethylamide moiety. LSD dissociates exceptionally slowly from both...
Neuroscience
March 27, 2015
C. Nocjar, Katherine D. Alex, Alex Sonneborn et al.
Neural function within the medial prefrontal cortex (mPFC) regulates normal cognition, attention and impulse control, implicating neuroregulatory abnormalities within this region in mental dysfunction related to schizophrenia, depression and drug abuse. Both serotonin -2A (5-HT2A) and -2C (5-HT2C) receptors are known to be important in neuropsychiatric drug action and are distributed throughout...
The Yale Journal of Biology and Medicine
2001
B. Roth
It is 10:00 Friday morning at the Yale School of Nursing in New Haven, Connecticut. I greet students as they arrive for the fifth session of an elective course entitled "The Stress Reduction and Relaxation Program." This eight week program provides intensive training in mindfulness meditation, and introduces meditation as a therapeutic intervention in the health care system. There are 20...