Muscarinic cannabinoid suppression of excitation, a novel form of coincidence detection.
Pharmacological Research February 1, 2025 Michaela Dvorakova, Ken Mackie, Alex Straiker 2 citations
Δ9-tetrahydrocannabinol (THC), the chief psychoactive ingredient of cannabis, acts in the brain primarily via cannabinoid CB1 receptors. These receptors are implicated in several forms of synaptic plasticity - depolarization-induced suppression of excitation (DSE), metabotropic suppression of excitation (MSE), long term depression (LTD) and activation-dependent desensitization. Cultured...
DOI: 10.1016/j.phrs.2025.107606 (opens in new tab)
Full text (opens in new tab)
Synaptic plasticity
Autaptic hippocampal neurons
Cb1 receptor
M3/m5 muscarinic receptors