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Michaela Dvorakova

1 paper in the library · 2 citations · publishing 2025

Papers

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Muscarinic cannabinoid suppression of excitation, a novel form of coincidence detection.

Pharmacological Research February 1, 2025 Michaela Dvorakova, Ken Mackie, Alex Straiker 2 citations

Δ9-tetrahydrocannabinol (THC), the chief psychoactive ingredient of cannabis, acts in the brain primarily via cannabinoid CB1 receptors. These receptors are implicated in several forms of synaptic plasticity - depolarization-induced suppression of excitation (DSE), metabotropic suppression of excitation (MSE), long term depression (LTD) and activation-dependent desensitization. Cultured...