Δ-9-Tetrahydrocannabinol and Cannabidiol produce dissociable effects on prefrontal cortical executive function and regulation of affective behaviors
Neuropsychopharmacology November 27, 2018 Hanna J Szkudlarek, Sagar Desai, Justine Renard et al. 63 citations
Acute infusions of THC directly into the prefrontal cortex of rats produce anxiety-like effects without impairing executive function, while CBD infusions impair attentional set-shifting and spatial working memory without affecting anxiety or sociability. CBD reverses cognitive impairments caused by glutamatergic antagonism in the prefrontal cortex and blocks the anxiety-inducing properties of THC, suggesting CBD's therapeutic effects may only emerge during pathological states. These opposing effects are mediated through dissociable CB1 and 5-HT1A receptor signaling mechanisms within the prefrontal cortex.