Acta VeterinariaJune 1, 2025Sava Ivaz, N. Puškaš, Bojana Paunović et al.
Abstract Phencyclidine (PCP), an antagonist of the N-methyl-D-aspartate glutamate receptor (NMDA-R), is used for modeling schizophrenia in animals, as NMDA-R hypofunction is vital in its pathophysiology. Recent studies have shown that glial fibrillary acidic protein (GFAP), an astrocyte marker, is altered in the prefrontal cortex and in certain hippocampal regions in individuals with...
Schizophrenia (SCH) is a mental disorder that requires long-term antipsychotic treatment. SCH patients are thought to have an increased sensitivity to stress. The dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis, observed in SCH, could include altered levels of glucocorticoids, glucocorticoid receptors (GRs), and associated proteins. The perinatal administration of phencyclidine...