The Effects of Perinatal Phencyclidine Administration on the Density and Branching of Astrocytes in the Brain of Aged Rats
Acta Veterinaria June 1, 2025 Sava Ivaz, N. Puškaš, Bojana Paunović et al.
Abstract Phencyclidine (PCP), an antagonist of the N-methyl-D-aspartate glutamate receptor (NMDA-R), is used for modeling schizophrenia in animals, as NMDA-R hypofunction is vital in its pathophysiology. Recent studies have shown that glial fibrillary acidic protein (GFAP), an astrocyte marker, is altered in the prefrontal cortex and in certain hippocampal regions in individuals with...