Caffeine and MDMA (ecstasy) exacerbate ER stress triggered by hyperthermia
bioRxiv (Cold Spring Harbor Laboratory) Kathleen A. Trychta, Brandon K. Harvey 1 citation preprint
Abstract Drugs of abuse can cause local and systemic hyperthermia, a known trigger of endoplasmic reticulum (ER) stress and the unfolded protein response (UPR). Another trigger of ER stress and UPR is ER calcium depletion which causes ER exodosis, the secretion of ER resident proteins. Club drugs such as 3,4-methylenedioxymethamphetamine (MDMA, ‘ecstasy’) can create hyperthermic conditions in...