The fly agaric, Amanita muscaria, is widely known for its content of the psychoactive metabolites ibotenic acid and muscimol. However, their biosynthetic pathway and the respective enzymes are entirely unknown. 50 years ago, the biosynthesis was hypothesized to start with 3-hydroxyglutamate. Here, we build on this hypothesis by the identification and recombinant production of a glutamate...
Neuroscience is a dynamically developing discipline which currently influences the emergence of new research programs that combine high-tech neuroscience methodology with social science approaches. This article focuses on neurophenomenology and fields of first-person neuroscience that attempt to bridge the gap between first-person and third-person perspectives of research. The aim of this...