The non-classic psychedelic muscimol suppresses inflammatory signaling and promotes neuroplasticity in schizophrenia-derived human cortical spheroids and astroglia
bioRxiv (Cold Spring Harbor Laboratory) April 12, 2026 Ibrahim A. Akkouh, Jordi Requena Osete, N. W. Steen et al. preprint
ABSTRACT Schizophrenia (SCZ) is increasingly linked to neuroimmune dysregulation and impaired synaptic plasticity, yet the cellular mechanisms connecting inflammatory signaling to neural dysfunction remain poorly understood. Using human induced pluripotent stem cell (iPSC)-derived cortical spheroids (hCS) and astrocytes from patients with SCZ and matched controls, we investigated the effects of...
DOI: 10.64898/2026.04.08.717305 (opens in new tab)
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Neuroplasticity
Synaptic plasticity
Muscimol
Gabaa receptor
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