ElifeApril 21, 2026Colin Bredenberg, Fabrice Normandin, Blake Richards et al.
Classical psychedelics induce complex visual hallucinations in humans, generating percepts that are coherent at a low level, but which have surreal, dream-like qualities at a high level. While there are many hypotheses as to how classical psychedelics could induce these effects, there are no concrete mechanistic models that capture the variety of observed effects in humans, while remaining...
ElifeJanuary 13, 2026Colin Bredenberg, Fabrice Normandin, Blake Richards et al.
Classical psychedelics induce complex visual hallucinations in humans, generating percepts that are coherent at a low level, but which have surreal, dream-like qualities at a high level. While there are many hypotheses as to how classical psychedelics could induce these effects, there are no concrete mechanistic models that capture the variety of observed effects in humans, while remaining...
Abstract We agree with Seth that consciousness is grounded in processes related to life, namely prediction, homeostasis, and autopoiesis. However, we believe he is wrong to frame these processes as non-computational. In fact, prediction, homeostasis, and autopoiesis are inherently computational, as shown by von Neumann’s Universal Constructor theory of general computation. Given this, we...