Ketamine induces delirium-like behavior and interferes with endosomal tau trafficking
Xinghua Ren, Siyi Zhang, Yongyan Yang et al.
Abstract Background Ketamine is an anesthetic and antidepressant drug. However, whether ketamine can induce neurotoxicity and neurobehavioral deficits remains largely unknown. Delirium is a syndrome of acute brain dysfunction that is very similar to the presentation after ketamine administration. The onset of postoperative delirium in patients is often accompanied by elevated tau in...