Eficácia e segurança da cetamina para o tratamento de depressão unipolar refratária: uma overview de revisões sistemáticas
Revista Brasileira de Farmácia Hospitalar e Serviços de Saúde December 26, 2024 Gabriela Ribeiro Pena, Fernando Henrique Teixeira Zonzini, Aline de Fátima Bonetti 1 citation
An overview of systematic reviews found that intravenous ketamine, typically at 0.5 mg/kg, reduces depressive symptoms and suicidal ideation in adults with treatment-resistant unipolar major depression. Improvement lasted 3 to 7 days; a single dose showed effects within 30 to 40 minutes. Adverse effects were mostly mild; two serious reactions (bradycardia and hypotension) did not cause dropout. However, 62% of the included reviews had critically low methodological quality. Ketamine appears effective and safe, but higher-quality studies are needed to determine optimal dosing.