Intron retention, a novel method for evaluating the response to ketamine in patients with treatment-resistant depression
Research Square Norihiro Okada, Kenshiro Oshima, Akiko Maruko et al.
Abstract In response to a state of stress, the body attempts to maintain protein homeostasis through intron retention (IR). In other words, by examining which genes undergo IR under stress (i.e., IR genes), it is possible to analyze what type of stress the body is experiencing (Okada et al. 2024 Front.Psychiatry). Using this principle, we re-analyzed the RNA-seq data of non-responders and...