Whole blood transcriptional signatures associated with rapid antidepressant response to ketamine in patients with treatment resistant depression
Translational Psychiatry January 10, 2022 F. Cathomas, L. Bevilacqua, Aarthi Ramakrishnan et al. 44 citations
Ketamine has rapid and sustained antidepressant effects in patients with treatment-resistant depression (TRD). However, the underlying mechanisms of action are not well understood. There is increasing evidence that TRD is associated with a pro-inflammatory state and that ketamine may inhibit inflammatory processes. We thus investigated whole blood transcriptional profiles related to TRD and...