Comparative EEG analysis of the effects of ketamine enantiomers and metabolites in rhesus macaques.
Journal of Neurophysiology April 1, 2026 Yoshihiro Iwamura, Kantaro Nishigori, Masataka Yamaguchi et al.
(R,S)-Ketamine, a dissociative anesthetic, has shown rapid and sustained antidepressant effects at lower doses than those required for anesthetic effects in patients with treatment-resistant depression. However, its use is limited because it causes side effects, including psychotomimetic symptoms and dependence. The enantiomer (R)-ketamine was reported to promote antidepressant-like effects in...