Yoshihiro Iwamura

Comparative EEG analysis of the effects of ketamine enantiomers and metabolites in rhesus macaques.

Journal of Neurophysiology April 1, 2026 Yoshihiro Iwamura, Kantaro Nishigori, Masataka Yamaguchi et al.

(R,S)-Ketamine, a dissociative anesthetic, has shown rapid and sustained antidepressant effects at lower doses than those required for anesthetic effects in patients with treatment-resistant depression. However, its use is limited because it causes side effects, including psychotomimetic symptoms and dependence. The enantiomer (R)-ketamine was reported to promote antidepressant-like effects in...