The Comparative Sensitivity to Ketamine-Induced Neuronal Death in Juvenile and Adult Rats.
International journal of toxicology June 4, 2026 Sumit Sarkar, Gonçalo Gamboa da Costa, Kellie Woodling et al.
Ketamine, an N-methyl-D-aspartate (NMDA) receptor antagonist, was first approved by the US FDA as KETALAR® for induction and maintenance of general anesthesia. Ketamine has been used off-label for depression treatment, while its S-enantiomer, esketamine (SPRAVATO®), is approved for treatment-resistant depression and major depressive disorder with acute suicidal ideation or behavior. High doses...