Niels Plath

2 papers in the library · publishing 2015-2018

Papers

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Temporally dissociable effects of ketamine on neuronal discharge and gamma oscillations in rat thalamo-cortical networks.

Neuropharmacology July 15, 2018 Maria Amat-Foraster, Anders A. Jensen, Niels Plath et al.

Sub-anesthetic doses of the non-competitive N-methyl-d-aspartate receptor (NMDA-R) antagonist ketamine evoke transient psychotomimetic effects, followed by persistent antidepressant effects in treatment-resistant depressed patients and rodents through still poorly understood mechanisms. Since phencyclidine (PCP) disinhibits thalamo-cortical networks by blocking NMDA-Rs on GABAergic neurons of...

DOI: 10.1016/j.neuropharm.2018.04.022 Full text Ketamine Local field potentials Nmda receptor antagonists Neuronal oscillations +2

The subchronic phencyclidine rat model: relevance for the assessment of novel therapeutics for cognitive impairment associated with schizophrenia.

Psychopharmacology November 2015 Sanna K Janhunen, Heta Svärd, John Talpos et al.

Current treatments for schizophrenia have modest, if any, efficacy on cognitive dysfunction, creating a need for novel therapies. Their development requires predictive animal models. The N-methyl-D-aspartate (NMDA) hypothesis of schizophrenia indicates the use of NMDA antagonists, like subchronic phencyclidine (scPCP) to model cognitive dysfunction in adult animals. The objective of this study...

DOI: 10.1007/s00213-015-3954-6 Full text Adult rat Cognition Schizophrenia Subchronic phencyclidine +3