Role of L-arginine/nitric oxide pathway in the antidepressant effects of ketamine
Zhonghua xingwei yixue yu naokexue zazhi September 20, 2012 Guang-Fen Zhang, Nan Wang, Jinyun Shi et al.
Objective To study the role of L-arginine/nitric oxide (NO) pathway in the antidepressant effects of ketamine. Methods Forty two male Wistar rats (200-250 g) were equally randomized into 7 groups (n=6): control group (C group), L-Arginine (a precursor of NO) group (LA group), L-NAME(an non-selectivity inhibitor of NO synthase) group (LN group), ketamine 3 mg/kg group (K3 group), ketamine 10...