Role of the medial prefrontal cortex in the effects of rapid acting antidepressants on decision-making biases in rodents
bioRxiv (Cold Spring Harbor Laboratory) January 23, 2020 Ca Hales, Jm Bartlett, Roberto Arban et al. preprint
Abstract Major Depressive Disorder is a significant and costly cause of global disability. Until the discovery of the rapid acting antidepressant (RAAD) effects of ketamine, treatments were limited to drugs that have delayed clinical benefits. The mechanism of action of ketamine is currently unclear but one hypothesis is that it may involve neuropsychological effects mediated through modulation...