Annamaria Cattaneo

2 papers in the library · 2 citations · publishing 2025-2026

Papers

The Effects of Mindfulness-Based Interventions on Physiological Markers of Stress in Older Adults: A Systematic Review and Synthesis

Mindfulness December 2, 2025 Samantha Galluzzi, Claudio Singh Solorzano, Moira Marizzoni et al. 2 citations

A systematic review of 22 controlled clinical trials found that mindfulness-based interventions (MBIs) such as mindfulness-based stress reduction and mindfulness-based cognitive therapy positively affect physiological markers of stress in older adults. The interventions influenced five stress-related systems: brain circuits and signaling, the sympathetic-adrenomedullary axis, the hypothalamus-pituitary-adrenal axis, the immune system, and gene expression and epigenetic mediators. Effects on brain circuits were observed in both clinical and community populations. The authors suggest these findings support the influence of MBIs on pathophysiological pathways related to chronic stress at a system level, though they note limitations including outcome heterogeneity, small sample sizes, and risk of bias.

DOI: 10.1007/s12671-025-02718-1 Full text Psychological intervention Population Mental illness Cognition +8

Distinct Molecular Responses to Ketamine and Imipramine in Cortical and Striatal Regions Following Acute Swim Stress

Biomolecules March 24, 2026 Veronica Begni, Floriana de Cillis, Natascha Pfeiffer et al.

Classical and rapid-acting antidepressants alter how the brain responds to acute stress through different molecular programs. In mice exposed to swim stress, imipramine dampened stress-induced neural activation in the cortex and striatum, while ketamine preserved it. Hippocampal activation remained robust and unaffected by either drug. BDNF expression changed only in the striatum, where imipramine reduced the stress-related increase. Both drugs similarly promoted active coping behaviors, but through distinct mechanisms. The findings suggest that cortical and striatal transcriptional signatures differentiate classical from rapid-acting antidepressant action, though human studies are needed to confirm clinical relevance.

DOI: 10.3390/biom16040484 Ketamine Neuroplasticity Imipramine Antidepressant +8