2 papers in the library · 1 citation · publishing 2022-2025
Brain Sciences May 6, 2025 Yang Bai 1 citation
Disorders of consciousness present ongoing challenges for clinicians and neurorehabilitation specialists because reliable assessment methods and effective interventions are lacking. The field is dynamic, but current approaches remain insufficient for accurately diagnosing or treating patients with these conditions.
Behavioural Brain Research July 1, 2022 Li-Min Zhang, Na Liu, Lucy Cao et al.
Pregnant mice given high-dose S-ketamine (60 mg/kg) all miscarried after the first injection. Low- and medium-dose S-ketamine (15 and 30 mg/kg) administered from gestational day 14 to 18 led to ADHD-like behaviors (increased open-arm time, reduced freezing in fear conditioning) and, at the medium dose, depression-like behaviors (reduced locomotion, increased immobility) in offspring. Changes in astrocytic activation, synaptic dysfunction, and decreased inhibitory presynaptic proteins were observed in the hippocampus, amygdala, and habenula nucleus. The authors conclude that S-ketamine may cause detrimental effects on developing brains and call for further study.