S-ketamine Administration in Pregnant Mice Induces ADHD- and Depression-like behaviors in Offspring Mice.
Behavioural Brain Research July 1, 2022 Li-Min Zhang, Na Liu, Lucy Cao et al.
BACKGROUND Anesthesia and psychotropic drugs in pregnant women may cause long-term effects on the brain development of unborn babies. The authors set out to investigate the neurotoxicity of S-ketamine, which possesses anesthetic and antidepressant effects and may cause attention deficit hyperactivity disorder (ADHD)- and depression-like behaviors in offspring mice. METHODS Pregnant mice were...