Commentary on Methods for Addressing Functional Unblinding and Mechanistic Uncertainty in Clinical Trials of Psychedelic-Assisted Treatments
Current Treatment Options in Psychiatry November 11, 2025 Dan Petrovitch, Sarah E. Victor, André Schmidt et al. 2 citations
Abstract Purpose of Review This commentary summarizes how the intense and distinctive subjective effects of psychedelics complicate tests of the efficacy and mechanisms of action (MOAs) of psychedelic-assisted treatments (PATs) for mental-health conditions. Specifically, we discuss (a) how estimates of PAT efficacy are confounded under functional unblinding and (b) uncertainty surrounding...
DOI: 10.1007/s40501-025-00371-y (opens in new tab)
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Clinical trial
Placebo
Medline
Action physics
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